Leptin resistance - or why leptin fails to work in obesity

被引：46

作者：

El-Haschimi, K ^{[1
]}

Lehnert, H ^{[1
]}

机构：

[1] Univ Magdeburg, Dept Endocrinol & Metab, D-39120 Magdeburg, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2003年 / 111卷 / 01期

关键词：

leptin; leptin resistance; STAT3; SOCS3; blood-brain-barrier;

D O I：

10.1055/s-2003-37492

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.

引用

页码：2 / 7

页数：6

共 66 条

[1] Role of leptin in the neuroendocrine response to fasting [J].

Ahima, RS ;

Prabakaran, D ;

Mantzoros, C ;

Qu, DQ ;

Lowell, B ;

MaratosFlier, E ;

Flier, JS .

NATURE, 1996, 382 (6588) :250-252

[2] Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse [J].

Arvaniti, K ;

Huang, OL ;

Richard, D .

NEUROENDOCRINOLOGY, 2001, 73 (04) :227-236

[3] Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity [J].

Banks, WA .

CURRENT PHARMACEUTICAL DESIGN, 2001, 7 (02) :125-133

[4] Enhanced leptin transport across the blood-brain barrier by α1-adrenergic agents [J].

Banks, WA .

BRAIN RESEARCH, 2001, 899 (1-2) :209-217

[5] Divergent signaling capacities of the long and short isoforms of the leptin receptor [J].

Bjorbaek, C ;

Uotani, S ;

da Silva, B ;

Flier, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :32686-32695

[6] Identification of SOCS-3 as a potential mediator of central leptin resistance [J].

Bjorbaek, C ;

Elmquist, JK ;

Frantz, JD ;

Shoelson, SE ;

Flier, JS .

MOLECULAR CELL, 1998, 1 (04) :619-625

[7] The role of SOCS-3 in leptin signaling and leptin resistance [J].

Bjorbæk, C ;

El-Haschimi, K ;

Frantz, JD ;

Flier, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :30059-30065

[8] Expression of leptin receptor isoforms in rat brain microvessels [J].

Bjorbæk, C ;

Elmquist, JK ;

Michl, P ;

Ahima, RS ;

van Bueren, A ;

McCall, AL ;

Flier, JS .

ENDOCRINOLOGY, 1998, 139 (08) :3485-3491

[9]

Boado RJ, 1998, J NEUROCHEM, V71, P1761

[10] Secretion of free and protein-bound leptin from subcutaneous adipose tissue of lean and obese women [J].

Brabant, G ;

Nave, H ;

Mayr, B ;

Behrend, M ;

van Harmelen, V ;

Arner, P .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (08) :3966-3970

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