Antibacterial evaluation of cnicin and some natural and semisynthetic analogues

被引：24

作者：

Bruno, M

Rosselli, S

Maggio, A

Raccuglia, RA

Napolitano, F

Senatore, F

机构：

[1] Univ Palermo, Dipartimento Chim Organ E Paterno, I-90128 Palermo, Italy

[2] Univ Naples, Dipartimento Farmacol Sperimentale, Naples, Italy

[3] Univ Naples, Dipartimento Chim Sostanze Nat, Naples, Italy

来源：

PLANTA MEDICA | 2003年 / 69卷 / 03期

关键词：

D O I：

10.1055/s-2003-38491

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Some ester derivatives of salonitenolide have been prepared from cnicin, a germacranolide sesquiterpenoid. The compounds were tested for their antibacterial activity. The 8,15-diesters showed a good activity, comparable with that of cnicin. The 15-monoester compounds were not very active showing that esterification at the C-8 position is an important structural feature for antibacterial properties.

引用

页码：277 / 281

页数：5

共 11 条

[1]

Barrero A. F., 1995, Fitoterapia, V66, P227

[2]

Barry A., 1976, ANTIMICROBIC SUSCEPT

[3] Sesquiterpene lactones and other constituents of Centaurea paniculata ssp castellana [J].