Imidazopyrimidines, potent inhibitors of p38 MAP kinase

被引：268

作者：

Rupert, KC ^{[1
]}

Henry, JR ^{[1
]}

Dodd, JH ^{[1
]}

Wadsworth, SA ^{[1
]}

Cavender, DE ^{[1
]}

Olini, GC ^{[1
]}

Fahmy, B ^{[1
]}

Siekierka, JJ ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, LLC, Drug Discovery, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)01020-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：347 / 350

页数：4

共 17 条

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