Rostral ventrolateral medullary opioid receptor activation modulates pressor response to muscle contraction

被引:21
作者
Caringi, D
Mokler, DJ
Koester, DM
Ally, A
机构
[1] Univ New England, Coll Osteopath Med, Dept Pharmacol, Biddeford, ME 04005 USA
[2] Univ New England, Coll Osteopath Med, Dept Biochem, Biddeford, ME 04005 USA
[3] Univ New England, Coll Osteopath Med, Dept Anat, Biddeford, ME 04005 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1998年 / 274卷 / 01期
关键词
caudal ventrolateral medulla; arterial pressure; rat; naloxone;
D O I
10.1152/ajpheart.1998.274.1.H139
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of an opioid agonist, [D-Ala(2)]methionine enkephalinamide (DAME), administered into the rostral ventrolateral medulla (rVLM) or caudal ventrolateral medulla (cVLM) on cardiovascular responses to isometric muscle contraction were determined in anesthetized rats. A 30-s contraction evoked by tibial nerve stimulation increased mean arterial pressure (MAP) and heart rate (HR) by 34 +/- 6 mmHg and 40 +/- 7 beats/min, respectively, with a developed tension of 322 +/- 30 g, after bilateral insertion of microdialysis probes into the rVLM. Thirty-minute dialysis of DAME (10 and 100 mu M) attenuated the contraction-evoked cardiovascular changes dose dependently (10 mu M: MAP = 25 +/- 4 mmHg, HR = 27 +/- 3 beats/min, tension = 333 +/- 25 g; 100 mu M: MAP = 14 +/- 4 mmHg, HR = 16 +/- 5 beats/min, tension = 330 +/- 34 g). Preadministration of an opioid antagonist, naloxone (100 mu M), augmented contraction-evoked MAP and HR responses and blocked effects of 100 mu M DAME. Microdialysis of DAME into the cVLM produced no changes in the presser response to contraction. At end of each experiment, tibial nerve stimulation after neuromuscular blockade evoked no MAP or HR change. Results demonstrate that opioid receptor activation within the rVLM modulates cardiovascular responses to isometric muscle contraction.
引用
收藏
页码:H139 / H146
页数:8
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