Interferon gamma-dependent transativation of epidermal growth factor receptor

被引：21

作者：

Burova, Elena ^{[1
]}

Vassilenko, Konstantin ^{[1
]}

Dorosh, Victoria ^{[1
]}

Gonchar, Ilya ^{[1
]}

Nikolsky, Nikolai ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol, Dept Intracellular Signaling & Transport, St Petersburg 194064, Russia

来源：

FEBS LETTERS | 2007年 / 581卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

IFN gamma; transactivation; epidermal growth factor receptor; STAT1; tyrosine phosphorylation;

D O I：

10.1016/j.febslet.2007.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present report provides evidence that, in A431 cells, interferon gamma (IFN gamma) induces the rapid (within 5 min), and reversible, tyrosine phosphorylation of the epidermal growth factor receptor (EGFR). IFN gamma-induced EGFR transactivation requires EGFR kinase activity, as well as activity of the Src-family tyrosine kinases and JAK2. Here, we show that IFN gamma-induced STAT1 activation in A431 and HeLa cells partially depends on the kinase activity of both EGFR and Src. Furthermore, in these cells, EGFR kinase activity is essential for IFN gamma-induced ERK1,2 activation. This study is the first to demonstrate that EGFR is implicated in IFN gamma-dependent signaling pathways. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1475 / 1480

页数：6

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