Translational control in cancer

被引：667

作者：

Silvera, Deborah ^{[1
]}

Formenti, Silvia C. ^{[1
,2
]}

Schneider, Robert J. ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

[2] NYU, Sch Med, Inst Canc, New York, NY 10016 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 04期

关键词：

DEPENDENT PROTEIN-KINASE; INTERNAL RIBOSOME ENTRY; SQUAMOUS-CELL CARCINOMA; INITIATION-FACTORS; 4E; INFLAMMATORY BREAST-CANCER; TUMOR-SUPPRESSOR PDCD4; MULTIPLE-MYELOMA CELLS; CAP-BINDING PROTEIN; EUKARYOTIC TRANSLATION; MALIGNANT-TRANSFORMATION;

D O I：

10.1038/nrc2824

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Remarkable progress has been made in defining a new understanding of the role of mRNA translation and protein synthesis in human cancer. Translational control is a crucial component of cancer development and progression, directing both global control of protein synthesis and selective translation of specific mRNAs that promote tumour cell survival, angiogenesis, transformation, invasion and metastasis. Translational control of cancer is multifaceted, involving alterations in translation factor levels and activities unique to different types of cancers, disease stages and the tumour microenvironment. Several clinical efforts are underway to target specific components of the translation apparatus or unique mRNA translation elements for cancer therapeutics.

引用

页码：254 / 266

页数：13

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