Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia

被引：7

作者：

Bartlett, MS

Shaw, MM

Smith, JW

Meshnick, SR

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[2] Indiana Univ, Med Ctr, Dept Lab Med & Pathol, Indianapolis, IN 46204 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 04期

关键词：

D O I：

10.1128/AAC.42.4.934

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.

引用

页码：934 / 935

页数：2

共 17 条

[1] ANAND N, 1980, BURGERS MED CHEM, P1
[2] INOCULATED MOUSE MODEL OF PNEUMOCYSTIS-CARINII INFECTION
BARTLETT, MS
QUEENER, SF
DURKIN, MM
SHAW, MA
SMITH, JW
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1992, 15 (02) : 129 - 134
[3] BJORKMAN A, 1991, B WORLD HEALTH ORGAN, V69, P297
[4] Trimethoprim/sulfamethoxazole desensitization
Cortese, LM
Soucy, DM
Endy, TP
[J]. ANNALS OF PHARMACOTHERAPY, 1996, 30 (02) : 184 - 186
[5] Cribb AE, 1996, ADVERSE DRUG REACT T, V15, P9
[6] FUNK KF, 1970, ACTA BIOL MED GER, V25, P151
[7] Evaluation of sulfa drugs against recombinant Pneumocystis carinii dihydropteroate synthetase and in vivo
Hong, YL
Hossler, P
Bartlett, M
Queener, S
Smith, J
Meshnick, S
[J]. JOURNAL OF EUKARYOTIC MICROBIOLOGY, 1996, 43 (05) : S40 - S40
[8] INHIBITION OF RECOMBINANT PNEUMOCYSTIS-CARINII DIHYDROPTEROATE SYNTHETASE BY SULFA DRUGS
HONG, YL
HOSSLER, PA
CALHOUN, DH
MESHNICK, SR
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (08) : 1756 - 1763
[9] CLINICAL MANIFESTATIONS OF AIDS IN THE ERA OF PNEUMOCYSTIS PROPHYLAXIS
HOOVER, DR
SAAH, AJ
BACELLAR, H
PHAIR, J
DETELS, R
ANDERSON, R
KASLOW, RA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (26) : 1922 - 1926
[10] Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia
Hughes, WT
Killmar, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (04) : 962 - 965

← 1 2 →