Cytokines and Other Mediators in Alopecia Areata

被引：87

作者：

Gregoriou, Stamatis ^{[1
]}

Papafragkaki, Dafni ^{[1
]}

Kontochristopoulos, George ^{[1
]}

Rallis, Eustathios ^{[1
]}

Kalogeromitros, Dimitrios ^{[1
]}

Rigopoulos, Dimitris ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Andreas Sygros Hosp, Athens 16121, Greece

来源：

MEDIATORS OF INFLAMMATION | 2010年 / 2010卷

关键词：

MIGRATION-INHIBITORY FACTOR; TUMOR-NECROSIS-FACTOR; MESSENGER-RNA LEVELS; HAIR FOLLICLE; T-CELLS; IN-VITRO; POLYMORPHISM; INTERLEUKIN-1-BETA; LYMPHOCYTES; INTERFERON;

D O I：

10.1155/2010/928030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-gamma, interleukins, TNF-alpha, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.

引用

页数：5

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