Longevity regulation in flies: A role for p53

被引：15

作者：

Donehower, Lawrence A. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

AGING-US | 2009年 / 1卷 / 01期

关键词：

LIFE-SPAN; MICE; EXPRESSION; ISOFORM; PATHWAY; FLY;

D O I：

10.18632/aging.100010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：6 / 8

页数：3

共 22 条

[1] Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors [J].

Akala, Omobolaji O. ;

Park, In-Kyung ;

Qian, Dalong ;

Pihalja, Michael ;

Becker, Michael W. ;

Clarke, Michael F. .

NATURE, 2008, 453 (7192) :228-U12

[2] Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span [J].

Bauer, JH ;

Poon, PC ;

Glatt-Deeley, H ;

Abrams, JM ;

Helfand, SL .

CURRENT BIOLOGY, 2005, 15 (22) :2063-2068

[3]

BAUER JH, 2009, AGING CELL IN PRESS, V1

[4] Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling [J].

Bauer, Johannes H. ;

Chang, Chengyi ;

Morris, Siti Nur Sarah ;

Hozier, Suzanne ;

Andersen, Sandra ;

Waitzman, Joshua S. ;

Helfand, Stephen L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (33) :13355-13360

[5] Senescence aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform [J].

Cao, L ;

Li, WM ;

Kim, S ;

Brodie, SG ;

Deng, CX .

GENES & DEVELOPMENT, 2003, 17 (02) :201-213

[6]

Donehower L., 2008, MOL BIOL AG, P127

[7] The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging [J].

Dumble, Melissa ;

Moore, Lynette ;

Chambers, Stuart M. ;

Geiger, Hartmut ;

Van Zant, Gary ;

Goodell, Margaret A. ;

Donehower, Lawrence A. .

BLOOD, 2007, 109 (04) :1736-1742

[8] 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally [J].

García-Cao, I ;

García-Cao, M ;

Martín-Caballero, J ;

Criado, LM ;

Klatt, P ;

Flores, JM ;

Weill, JC ;

Blasco, MA ;

Serrano, M .

EMBO JOURNAL, 2002, 21 (22) :6225-6235

[9]

IMAI SI, 2008, MOL BIOL AG, P39

[10]

Janzen V., 2006, Nature

← 1 2 3 →