Ubiquitin: structures, functions, mechanisms

被引：1057

作者：

Pickart, CM

Eddins, MJ

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1695卷 / 1-3期

基金：

美国国家卫生研究院;

关键词：

E1; E2; E3; Nedd8; Sumo; Ubc; ubiquitin;

D O I：

10.1016/j.bbamcr.2004.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins. thereby changing the stability, localization, or activity of the target protein. This article reviews the basic biochemistry of these protein conjugation reactions. focusing on ubiquitin itself and emphasizing recent insights into mechanism and specificity. (C) 2004 Elsevier B.V. All rights reserved.

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页码：55 / 72

页数：18

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