Running Per Se Stimulates the Dendritic Arbor of Newborn Dentate Granule Cells in Mouse Hippocampus in a Duration-Dependent Manner

被引:23
作者
Dostes, Sandrine [1 ,2 ,3 ]
Dubreucq, Sarah [1 ,3 ]
Ladeveze, Elodie [2 ,3 ]
Marsicano, Giovanni [1 ,3 ]
Abrous, Djoher N. [2 ,3 ]
Chaouloff, Francis [1 ,3 ]
Koehl, Muriel [2 ,3 ]
机构
[1] Neuroctr Magendie, Endocannabinoids & NeuroAdaptat Grp, Bordeaux, France
[2] NeuroCtr Magendie, Neurogenesis & Physiopathol Grp, F-33076 Bordeaux, France
[3] Univ Bordeaux Segalen, Bordeaux, France
基金
欧盟第七框架计划; 欧洲研究理事会;
关键词
adult neurogenesis; hippocampus; exercise; running wheel; enrichment; mice; VOLUNTARY EXERCISE; PHYSICAL-EXERCISE; BDNF LEVELS; WATER MAZE; NEUROGENESIS; PROLIFERATION; ANXIETY; ENVIRONMENT; COMPLEXITY; DEPRESSION;
D O I
10.1002/hipo.22551
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Laboratory rodents provided chronic unlimited access to running wheels display increased neurogenesis in the hippocampal dentate gyrus. In addition, recent studies indicate that such an access to wheels stimulates dendritic arborization in newly formed neurons. However, (i) the presence of the running wheel in the housing environment might also bear intrinsic influences on the number and shape of new neurons and (ii) the dendritic arborization of new neurons might be insensitive to moderate daily running activity (i.e., several hours). In keeping with these uncertainties, we have examined neurogenesis and dendritic arborization in newly formed granular cells in adult C57Bl/6N male mice housed for 3 weeks under standard conditions, with a locked wheel, with a running wheel set free 3 h/day, or with a running wheel set permanently free. The results indicate that the presence of a blocked wheel in the home cage increased cell proliferation, but not the number of new neurons while running increased in a duration-dependent manner the number of newborn neurons, as assessed by DCX labeling. Morphological analyses of the dendritic tree of newborn neurons, as identified by BrdU-DCX co-staining, revealed that although the presence of the wheel stimulated their dendritic architecture, the amplitude of this effect was lower than that elicited by running activity, and was found to be running duration-dependent. (C) 2015Wiley Periodicals, Inc.
引用
收藏
页码:282 / 288
页数:7
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