Conduit for privileged communications in the lymph node

被引：26

作者：

Anderson, AO ^{[1
]}

Shaw, S

机构：

[1] USA, Med Res Inst Infect Dis, Dept Clin Pathol, Frederick, MD 21702 USA

[2] NCI, Expt Immunol Branch, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2005年 / 22卷 / 01期

关键词：

D O I：

10.1016/j.immuni.2005.01.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A study by Sixt et al. in this issue of Immunity identifies conduit-associated dendritic cells whose privileged access to antigen arriving by the conduit enables uptake and processing of antigen within 90 min of antigen inoculation, long before the arrival of dendritic cells from skin.

引用

页码：3 / 5

页数：3

共 11 条

[1]

Anderson A O, 1993, Semin Immunol, V5, P271, DOI 10.1006/smim.1993.1031

[2] The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation [J].

Bajénoff, M ;

Granjeaud, S ;

Guerder, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (05) :715-724

[3] Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex [J].

Gretz, JE ;

Norbury, CC ;

Anderson, AO ;

Proudfoot, AEI ;

Shaw, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1425-1439

[4]

Gretz JE, 1996, J IMMUNOL, V157, P495

[5] DIRECT CONTACT BETWEEN RETICULAR FIBERS AND MIGRATORY CELLS IN THE PARACORTEX OF MOUSE LYMPH-NODES - A MORPHOLOGICAL AND QUANTITATIVE STUDY [J].

HAYAKAWA, M ;

KOBAYASHI, M ;

HOSHINO, T .

ARCHIVES OF HISTOLOGY AND CYTOLOGY, 1988, 51 (03) :233-240

[6] In situ analysis reveals physical interactions between CD11b+ dendritic cells and antigen-specific CD4 T cells after subcutaneous injection of antigen [J].

Ingulli, E ;

Ulman, DR ;

Lucido, MM ;

Jenkins, MK .

JOURNAL OF IMMUNOLOGY, 2002, 169 (05) :2247-2252

[7] Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity [J].

Itano, AA ;

McSorley, SJ ;

Reinhardt, RL ;

Ehst, BD ;

Ingulli, E ;

Rudensky, AY ;

Jenkins, MK .

IMMUNITY, 2003, 19 (01) :47-57

[8] Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix [J].

Kaldjian, EP ;

Gretz, JE ;

Anderson, AO ;

Shi, YH ;

Shaw, S .

INTERNATIONAL IMMUNOLOGY, 2001, 13 (10) :1243-1253

[9] A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells [J].

Katakai, T ;

Hara, T ;

Lee, JH ;

Gonda, H ;

Sugai, M ;

Shimizu, A .

INTERNATIONAL IMMUNOLOGY, 2004, 16 (08) :1133-1142

[10] The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node [J].

Sixt, M ;

Kanazawa, N ;

Seig, M ;

Samson, T ;

Roos, G ;

Reinhardt, DP ;

Pabst, R ;

Lutz, MB ;

Sorokin, L .

IMMUNITY, 2005, 22 (01) :19-29

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