Protein interactions and fluctuations in a proteomic network using an elastic network model

被引：17

作者：

Demirel, MC ^{[1
]}

Keskin, O

机构：

[1] Penn State Univ, Coll Engn, University Pk, PA 16802 USA

[2] Koc Univ, Ctr Computat Biol & Bioinformat, TR-34450 Istanbul, Turkey

[3] Koc Univ, Coll Engn, TR-34450 Istanbul, Turkey

[4] NCI, Lab Expt & Computat Biol, NIH, Frederick, MD 21702 USA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2005年 / 22卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07391102.2005.10507010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A set of protein conformations are analyzed by normal mode analysis. An elastic network model is used to obtain fluctuation and cooperativity of residues with low amplitude fluctuations across different species. Slow modes that are associated with the function of proteins have common features among different protein structures. We show that the degree of flexibility of the protein is important for proteins to interact with other proteins and as the species gets more complex its proteins become more flexible. In the complex organism. higher cooperativity arises due to protein structure and connectivity.

引用

页码：381 / 386

页数：6

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