Delayed rectifier potassium currents induced in activated rat microglia set the resting membrane potential

被引：22

作者：

Chung, S ^{[1
]}

Joe, E

Soh, H

Lee, MY

Bang, HW

机构：

[1] Chung Ang Univ, Coll Med, Dept Physiol, Seoul 156756, South Korea

[2] Ajou Univ, Sch Med, Dept Pharmacol, Suwon 442749, South Korea

来源：

NEUROSCIENCE LETTERS | 1998年 / 242卷 / 02期

关键词：

microglia; delayed rectifier K+ channel; lipopolysaccharide; resting membrane potential; 4-aminopyridine;

D O I：

10.1016/S0304-3940(98)00029-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The delayed rectifying outward K+ (I-K) current was measured in lipopolysaccharide (LPS)-activated cultured rat microglial cells by using whole-cell patch clamp method. The current showed 'window current' where channels were available for activation but never fully inactivated. At near resting membrane potential some part of the current was able to be activated by depolarization. Among the several K+ channel blockers tested, only 4-aminopyridine (4-AP) was able to block most of the current and depolarize the membrane potential reversibly. These results suggest that 4-AP sensitive I-K current plays a direct role of setting the resting membrane potential in LPS-activated microglia. (C) 1998 Elsevier Science ireland Ltd.

引用

页码：73 / 76

页数：4

共 16 条

[1]

Defarias FP, 1995, RECEPTOR CHANNEL, V3, P273

[2] CHARACTERIZATION OF MICROGLIA AND MACROPHAGES IN THE CENTRAL-NERVOUS-SYSTEM OF RATS - DEFINITION OF THE DIFFERENTIAL EXPRESSION OF MOLECULES USING STANDARD AND NOVEL MONOCLONAL-ANTIBODIES IN NORMAL CNS AND IN 4 MODELS OF PARENCHYMAL REACTION [J].