Dose-related reduction in allergen-specific T cells associates with clinical response of atopic dermatitis to methotrexate

被引：5

作者：

Bateman, E. A. L.

Ardern-Jones, M.

Ogg, G. S. ^{[1
]}

机构：

[1] Univ Oxford, MRC, Human Immunol Unit, John Radcliffe Hosp,Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Churchill Hosp, Dept Dermatol, Oxford OX3 7LJ, England

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2007年 / 156卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1111/j.1365-2133.2007.07879.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

引用

页码：1376 / 1377

页数：3

共 10 条

[1] Successful treatment of severe atopic dermatitis with methotrexate [J].

Balasubramaniam, P ;

Ilchyshyn, A .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2005, 30 (04) :436-437

[2] Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1*0101 tetramer-binding CD4+ T cells [J].

Bateman, Elizabeth Alice Louise ;

Ardern-Jones, Michael Roger ;

Ogg, Graham Stuart .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (06) :1350-1356

[3] Six area, six sign atopic dermatitis (SASSAD) severity score: A simple system for monitoring disease activity in atopic dermatitis [J].

BerthJones, J .

BRITISH JOURNAL OF DERMATOLOGY, 1996, 135 :25-30

[4] Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells [J].

Genestier, L ;

Paillot, R ;

Fournel, S ;

Ferraro, C ;

Miossec, P ;

Revillard, JP .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (02) :322-328

[5]

Goujon C, 2006, EUR J DERMATOL, V16, P155

[6] Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions [J].

Haselden, BM ;

Kay, AB ;

Larché, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (12) :1885-1894

[7] The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules [J].

Johnston, A ;

Gudjonsson, JE ;

Sigmundsdottir, H ;

Ludviksson, BR ;

Valdimarsson, H .

CLINICAL IMMUNOLOGY, 2005, 114 (02) :154-163

[8] Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase-mediated conversion of adenine nucleotides [J].

Morabito, L ;

Montesinos, MC ;

Schreibman, DM ;

Balter, L ;

Thompson, LF ;

Resta, R ;

Carlin, G ;

Huie, MA ;

Cronstein, BN .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :295-300

[9] Experience with low-dose methotrexate for the treatment of eczema in the elderly [J].

Shaffrali, FCG ;

Colver, GB ;

Messenger, AG ;

Gawkrodger, DJ .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (03) :417-419

[10] Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin [J].

Sigmundsdottir, H ;

Johnston, A ;

Gudjonsson, JE ;

Bjarnason, B ;

Valdimarsson, H .

EXPERIMENTAL DERMATOLOGY, 2004, 13 (07) :426-434

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