Influence of hypoxia and hyperthermia upon peroxidative and glutathione status in growth-restricted newborn piglets

被引：6

作者：

Barth, A

Bauer, R

Gedrange, T

Walter, B

Linss, C

Klinger, W

机构：

[1] Friedrich Schiller Univ, Inst Pharmacol & Toxicol, D-07743 Jena, Germany

[2] Friedrich Schiller Univ, Inst Pathol Physiol, D-07743 Jena, Germany

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 1998年 / 50卷 / 01期

关键词：

newborn piglets; hypoxia; hyperthermia; oxygen free radicals; glutathione;

D O I：

10.1016/S0940-2993(98)80059-6

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Normal weight (NW) and spontaneously intra-uterine growth-restricted newborn piglets (IUGR) were submitted to 1 hour hypoxia and hyperthermia followed by 3 hours reoxygenation. Glutathione (GSH, GSSG), lipid peroxidation products (TEAR) and cytochrome P450 dependent production of reactive oxygen species were studied by determination of H2O2 production and amplified chemiluminescence (CL) in brain and peripheral organs of NW and IUGR. A severe decrease of GSH was accompanied by enhanced H2O2 formation and lipid peroxidation in the brain of both NW and IUGR after hypoxia/hyperthermia and reoxygenation. In the other organs studied, only muscles showed enhanced lucigenine amplified CL and TEAR production. Nearly the same results in NW and IUGR reveal no higher risk of IUGR.

引用

页码：31 / 33

页数：3

共 13 条

[1] NEW ASPECTS OF BRAIN OXIDATIVE STRESS-INDUCED BY TERT-BUTYLHYDROPEROXIDE [J].