New structural and chemical insight into the catalytic mechanism of epoxide hydrolases

被引：36

作者：

Armstrong, RN

Cassidy, CS

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Chem, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA

来源：

DRUG METABOLISM REVIEWS | 2000年 / 32卷 / 3-4期

关键词：

hydrolysis; epoxide; covalent intermediate; electrophilic catalysis;

D O I：

10.1081/DMR-100102337

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

New structural and mechanistic data on epoxide hydrolases provide additional insight into the details of how these enzymes function. The data reveal that, in addition to the catalytic triad located in the core domain that carries out the hydrolytic reaction, there are two tyrosine residues, located in the cap domain, which assist in the initial alkylation event.

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页码：327 / 338

页数：12

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