Perspectives in Adjuvant Therapy of Gastric Cancer

被引：21

作者：

De Vita, Ferdinando ^{[1
]}

Vecchione, Loredana ^{[1
]}

Galizia, Gennaro ^{[1
]}

Di Martino, Natale ^{[1
]}

Fabozzi, Teresa ^{[1
]}

Catalano, Giuseppe ^{[1
]}

Ciardiello, Fortunato ^{[1
]}

Orditura, Michele ^{[1
]}

机构：

[1] Univ Naples 2, Div Digest Surg 8, Dept Clin & Expt Med F Magrassi & A Lanzara, IT-80131 Naples, Italy

来源：

ONCOLOGY | 2009年 / 77卷

关键词：

Adjuvant chemotherapy; Anti-EGFR drugs; Chemoradiotherapy; C-ERBB-2 PROTEIN EXPRESSION; PHASE-III TRIAL; CURATIVE RESECTION; GENE AMPLIFICATION; CHEMOTHERAPY; METAANALYSIS; SURGERY; OVEREXPRESSION; ADENOCARCINOMA; 5-FLUOROURACIL;

D O I：

10.1159/000258494

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates are disappointing due to locoregional relapse and distant metastases. This emphasizes the importance of multidisciplinary management of patients with gastric cancer. In contrast to the preoperative approach, several phase III trials have been carried out in the adjuvant setting, but postoperative chemotherapy has not proven to be superior to surgery alone. Therefore, at present the routine use of adjuvant therapy should be regarded as an investigational approach. Improved clinical trial designs with standardized surgical techniques and the incorporation of newer active drugs are needed. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：38 / 42

页数：5

共 46 条

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