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Liver regeneration: From myth to mechanism

被引：1211
作者：
Taub, R [1 ]
机构：
[1] Univ Penn, Sch Med, Philadelphia, PA 19004 USA
[2] Hoffmann La Roche Inc, Metab Dis, Nutley, NJ 07110 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 10期
关键词：
D O I：
10.1038/nrm1489
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The unusual regenerative properties of the liver are a logical adaptation by organisms, as the liver is the main detoxifying organ of the body and is likely to be injured by ingested toxins. The numerous cytokine- and growth-factor-mediated pathways that are involved in regulating liver regeneration are being successfully dissected using molecular and genetic approaches. So what is known about this process at present and which questions remain?
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页码：836 / 847
页数：12
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