A stereoselective synthesis of (+)-malyngolide via a ring-closing olefin metathesis

被引:22
作者
Carda, M
Castillo, E
Rodríguez, S
Marco, JA [1 ]
机构
[1] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain
[2] Univ Jaume 1, Dept Quim Inorgan & Organ, E-12080 Castellon, Spain
关键词
malyngolide; ring-closing metathesis; diastereoselective allyltin addition;
D O I
10.1016/S0040-4039(00)00884-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A very short and stereoselective synthesis of the non-natural enantiomer of malyngolide from L-erythrulose is described. Key features of the synthesis are the Felkin-Anh diastereoselective allylation of a poly oxygenated ketone and the allylation/metathesis/allylic oxidation protocol recently described by our group. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:5511 / 5513
页数:3
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