Pd-PEPPSI-IPent: Low-Temperature Negishi Cross-Coupling for the Preparation of Highly Functionalized, Tetra-ortho-Substituted Biaryls

被引：128

作者：

Calimsiz, Selcuk ^{[1
]}

Sayah, Mahmoud ^{[1
]}

Mallik, Debasis ^{[1
]}

Organ, Michael G. ^{[1
]}

机构：

[1] York Univ, Dept Chem, N York, ON M3J 1P3, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

biaryls; cross-coupling; heteroaryls; Negishi reaction; palladium; ORGANOZINC REAGENTS; CATALYST; ARYL; IMPROVEMENT; CHLORIDES; ACIDS; STEP;

D O I：

10.1002/anie.200906811

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Cool couplings: Complex, hindered biaryls have been prepared at temperatures ranging from 0°C to room temperature, or with gentle heating. The Pd-PEPPSI-IPent catalyst (see scheme) nicely couples starting materials containing acidic moieties and routinely prepares biaryl derivatives where one or both rings comprising the biaryl are heterocyclic. Ar1=hindered aryl or heteroaryl, Ar2=unactivated aryl or heteroaryl. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2014 / 2017

页数：4

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[2]

Bringmann G., 2001, PROGR CHEM ORGANIC N, V82

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