Effect of aluminum (III) on the conversion of dopachrome in the melanin synthesis pathway

被引：11

作者：

Di, JW

Bi, SP ^{[1
]}

机构：

[1] Nanjing Univ, Dept Chem, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

[2] Suzhou Univ, Dept Chem, Suzhou 215006, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2003年 / 59卷 / 08期

基金：

中国国家自然科学基金;

关键词：

dopachrome conversion; melanin; 5,6-dihydroxyindole; aluminum ion;

D O I：

10.1016/S1386-1425(02)00403-1

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The effect of aluminum ions on the kinetics and mode of the conversion of dopachrome (DC) in acidic environment has been studied using UV-Vis spectrophotometric and cyclic voltammetric methods. The DC conversion step is an important reaction in melanogenesis. Aluminum ions catalyze greatly the decarboxylative transformation of DC to give 5,6-dihydroxyindole (DHI) rather than 5,6-dihydroxyindole-2-carboxylic acid (DHICA) at pH 5.5, which enhance the ratio of formation DHI/DHICA in melanin synthesis pathway. The kinetics of DC conversion catalyzed by aluminum ions is dependent on the concentration of DC and aluminum ions. These results provide evidence that aluminum ions could play a role in the synthesis of melanin pathway in acidic condition through catalyzing the DC decarboxylative transformation to yield DHI and influence the melanin structure and properties. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1689 / 1696

页数：8

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