Cancer - Sheep, lilies and human genetics

被引：11

作者：

Bale, AE ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

来源：

NATURE | 2000年 / 406卷 / 6799期

关键词：

D O I：

10.1038/35023197

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies of an epidemic of sheep cyclopia in the western United States have led to a possible treatment for human skin cancer. The compound that caused the cyclopia inhibits the Hedgehog cellular signalling pathway, which is activated in most basal-cell carcinomas.

引用

页码：944 / 945

页数：2

共 9 条

[1] Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly [J].

Belloni, E ;

Muenke, M ;

Roessler, E ;

Traverso, G ;

SiegelBartelt, J ;

Frumkin, A ;

Mitchell, HF ;

DonisKeller, H ;

Helms, C ;

Hing, AV ;

Heng, HHQ ;

Koop, B ;

Martindale, D ;

Rommens, JM ;

Tsui, LC ;

Scherer, SW .

NATURE GENETICS, 1996, 14 (03) :353-356

[2] Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].

Chiang, C ;

Ying, LTT ;

Lee, E ;

Young, KE ;

Corden, JL ;

Westphal, H ;

Beachy, PA .

NATURE, 1996, 383 (6599) :407-413

[3] Teratogen-mediated inhibition of target tissue response to Shh signaling [J].

Cooper, MK ;

Porter, JA ;

Young, KE ;

Beachy, PA .

SCIENCE, 1998, 280 (5369) :1603-1607

[4] Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome [J].

Hahn, H ;

Wicking, C ;

Zaphiropoulos, PG ;

Gailani, MR ;

Shanley, S ;

Chidambaram, A ;

Vorechovsky, I ;

Holmberg, E ;

Unden, AB ;

Gillies, S ;

Negus, K ;

Smyth, I ;

Pressman, C ;

Leffell, DJ ;

Gerrard, B ;

Goldstein, AM ;

Dean, M ;

Toftgard, R ;

ChenevixTrench, G ;

Wainwright, B ;

Bale, AE .

CELL, 1996, 85 (06) :841-851

[5]

Incardona JP, 1998, DEVELOPMENT, V125, P3553

[6] TERATOGENIC COMPOUNDS OF VERATRUM CALIFORNICUM (DURAND) .V. COMPARISON OF CYCLOPIAN EFFECTS OF STEROIDAL ALKALOIDS FROM PLANT AND STRUCTURALLY RELATED COMPOUNDS FROM OTHER SOURCES [J].

KEELER, RF ;

BINNS, W .

TERATOLOGY, 1968, 1 (01) :5-&

[7] Mutations in the human Sonic hedgehog gene cause holoprosencephaly [J].

Roessler, E ;

Belloni, E ;

Gaudenz, K ;

Jay, P ;

Berta, P ;

Scherer, SW ;

Tsui, LC ;

Muenke, M .

NATURE GENETICS, 1996, 14 (03) :357-360

[8] Is human patched the gatekeeper of common skin cancers? [J].

Sidransky, D .

NATURE GENETICS, 1996, 14 (01) :7-8

[9] Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine [J].

Taipale, J ;

Chen, JK ;

Cooper, MK ;

Wang, BL ;

Mann, RK ;

Milenkovic, L ;

Scott, MP ;

Beachy, PA .

NATURE, 2000, 406 (6799) :1005-1009

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