A distinct FMRP polysomal population at an advanced stage of mammalian erythropoiesis

被引：4

作者：

Beaulieu, MA ^{[1
]}

机构：

[1] Univ Laval, Fac Med, Programme Biol Mol & Cellulaire, St Foy, PQ G1K 7P4, Canada

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 275卷 / 02期

关键词：

FMRP; polyribosomes; KH mRNA binding protein; erythropoiesis; fragile-X syndrome; regulation of translation;

D O I：

10.1006/bbrc.2000.3313

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fragile-X syndrome is a mental disorder caused by the absence of FMRP (the Fragile-X Mental Retardation Protein). While FMRP is found to be associated with the ribosomal components, its precise translational function remains to be defined. Here we report that FMRP is not found with the abundant free polysomes of the reticulocyte lysate, but rather with a heavy ribonucleoprotein complex sedimenting over 400S. This unusual distribution of FMRP at an advanced stage of mammalian erythropoiesis may unveil the discrete role of FMRP in translation. (C) 2000 Academic Press.

引用

页码：608 / 610

页数：3

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