Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA

被引:114
作者
Conway, DJ
Fanello, C
Lloyd, JM
Al-Joubori, BMAS
Baloch, AH
Somanath, SD
Roper, C
Oduola, AMJ
Mulder, B
Povoa, MM
Singh, B
Thomas, AW
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[2] Univ Ibadan, Coll Med, Ibadan, Nigeria
[3] OCEAC, Malaria Dept, Yaounde, Cameroon
[4] Inst Evandro Chagas, Serv Parasitol, Belem, Para, Brazil
[5] Univ Malaysia Sarawak, Kota Samarahan 94300, Sarawak, Malaysia
[6] Biomed Primate Res Ctr, NL-2288 GH Rijswijk, Netherlands
基金
英国惠康基金;
关键词
Plasmodium falciparum; Plasmodium reichenowi; mitochondrial genome; genetics; species; evolution;
D O I
10.1016/S0166-6851(00)00313-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The origin and geographical spread of Plasmodium falciparum is here determined by analysis of mitochondrial DNA sequence polymorphism and divergence from its most closely related species P. reichenowi (a rare parasite of chimpanzees). The complete 6 kb mitochondrial genome was sequenced from the single known isolate of P. reichenowi and from four different cultured isolates of P. falciparum, and aligned with the two previously derived P. falciparum sequences. The extremely low synonymous nucleotide polymorphism in P. falciparum (pi = 0.0004) contrasts with the divergence at such sites between the two species (K = 0.1201), and supports a hypothesis that P. falciparum has recently emerged from a single ancestral population. To survey the geographical distribution of mitochondrial haplotypes in P. falciparum, 104 isolates from several endemic areas were typed for each of the identified single nucleotide polymorphisms. The haplotypes show a radiation out of Africa, with unique types in Southeast Asia and South America being related to African types by single nucleotide changes. This indicates that P. falciparum originated in Africa and colonised Southeast Asia and South America separately. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:163 / 171
页数:9
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