Pseudoprolines as removable turn inducers: Tools for the cyclization of small peptides

被引：73

作者：

Skropeta, D ^{[1
]}

Jolliffe, KA ^{[1
]}

Turner, P ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 25期

关键词：

D O I：

10.1021/jo0484732

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.

引用

页码：8804 / 8809

页数：6

共 26 条

[1]

[Anonymous], 1986, NMR or Proteins and Nucleic Acids.: Polypeptide Secondary Structures in Proteins by NMR

[2]

Bystrov V. F., 1976, PROGR NMR SPECTROSCO, V10, P41

[3] HOW TO PERFORM SMALL PEPTIDE CYCLIZATIONS [J].