Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

被引：37

作者：

Miyamoto, T

Gondo, H

Miyoshi, Y

Shigematsu, H

Minematsu, T

Takenaka, K

Tanimoto, K

Horiuchi, T

Asano, Y

Inaba, S

Minamishima, Y

Niho, Y

机构：

[1] Kyushu Univ, Fac Med, Blood Transfus Serv, Fukuoka 812, Japan

[2] Kyushu Univ, Fac Med, Dept Internal Med 1, Fukuoka 812, Japan

[3] Miyazaki Med Coll, Dept Microbiol, Miyazaki 88916, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 100卷 / 02期

关键词：

CD34(+) cells; stem cell transplantation; immunodeficiency; viral infection;

D O I：

10.1046/j.1365-2141.1998.00572.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with non-Hodgkin's lymphoma who received a CD34-selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus-associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft and a persistent decrease in CD4(+) lymphocytes following PBSCT may have predisposed this patient to such viral infections. Infusion of cryopreserved autologous PBSC (containing mature T cells) was effective for adenovirus-associated HC. Immunosuppression and resultant viral infections may affect patients receiving CD34-selected autologous transplantation.

引用

页码：348 / 350

页数：3

共 10 条

[1] ANDERSON KC, 1990, BLOOD, V76, P235
[2] DIGIUSTO D, 1994, BLOOD, V84, P421
[3] EINSELE H, 1993, BLOOD, V82, P1672
[4] CYTOMEGALOVIRUS (CMV) ANTIGENEMIA FOR RAPID DIAGNOSIS AND MONITORING OF CMV-ASSOCIATED DISEASE AFTER BONE-MARROW TRANSPLANTATION
GONDO, H
MINEMATSU, T
HARADA, M
AKASHI, K
HAYASHI, S
TANIGUCHI, S
YAMASAKI, K
SHIBUYA, T
TAKAMATSU, Y
TESHIMA, T
ETO, T
NAGAFUJI, K
MIZUNO, S
HOSODA, K
MORI, R
MINAMISHIMA, Y
NIHO, Y
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1994, 86 (01) : 130 - 137
[5] Greer John P., 1993, P2082
[6] HERTENSTEIN B, 1995, BONE MARROW TRANSPL, V15, P387
[7] MACKALL CL, 1993, BLOOD, V82, P2585
[8] NOGA SJ, 1997, GRAFTVERSUSHOST DIS, P717
[9] PARKMAN R, 1994, BONE MARROW TRANSPL, P504
[10] TESHIMA T, 1992, BONE MARROW TRANSPL, V10, P215

← 1 →