Laminar circuit formation in the vertebrate retina

被引:37
作者
Mumm, JS [1 ]
Godinho, L [1 ]
Morgan, JL [1 ]
Oakley, DM [1 ]
Schroeter, EH [1 ]
Wong, ROL [1 ]
机构
[1] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
来源
DEVELOPMENT, DYNAMICS AND PATHOLOGY OF NEURONAL NETWORKS: FROM MOLECULES TO FUNCTIONAL CIRCUITS | 2005年 / 147卷
关键词
D O I
10.1016/S0079-6123(04)47012-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuronal function depends on the accurate wiring between pre- and postsynaptic cells. Determining the mechanisms underlying precision in neuronal connectivity is challenging because of the complexity of the nervous system. In diverse parts of the nervous system, regions of synaptic contact are organized into distinct parallel layers, or laminae, that are correlated with distinct functions. Such an arrangement enables the development of synapse specificity to be more readily investigated. Here, we present an overview of the developmental mechanisms that are thought to underlie the formation of synaptic layers in the vertebrate retina, a highly laminated CNS structure. We will contrast the roles of activity-dependent and activity-independent mechanisms in establishing functionally discrete sublaminae in the inner retina, where circuits involving many subtypes of retinal neurons are assembled precisely. In addition, we will discuss new optical imaging approaches for elucidating how retinal synaptic lamination occurs in vivo.
引用
收藏
页码:155 / 169
页数:15
相关论文
共 84 条
[1]  
AVENSOV A, 2003, 3 EUR C ZEBR MED GEN, P5
[2]  
Bansal A, 2000, J NEUROSCI, V20, P7672
[3]  
Bisti S, 1998, J NEUROSCI, V18, P5019
[4]   STRATIFICATION OF ON AND OFF GANGLION-CELL DENDRITES DEPENDS ON GLUTAMATE-MEDIATED AFFERENT ACTIVITY IN THE DEVELOPING RETINA [J].
BODNARENKO, SR ;
CHALUPA, LM .
NATURE, 1993, 364 (6433) :144-146
[5]  
BODNARENKO SR, 1995, J NEUROSCI, V15, P7037
[6]   Necessity for afferent activity to maintain eye-specific segregation in ferret lateral geniculate nucleus [J].
Chapman, B .
SCIENCE, 2000, 287 (5462) :2479-2482
[7]   Sperry and Hebb: oil and vinegar? [J].
Cline, H .
TRENDS IN NEUROSCIENCES, 2003, 26 (12) :655-661
[8]   Expression of axonin-1 in developing amacrine cells in the chick retina [J].
Drenhaus, U ;
Morino, P ;
Rager, G .
JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 468 (04) :496-508
[9]   On the development of the stratification of the inner plexiform layer in the chick retina [J].
Drenhaus, U ;
Morino, P ;
Veh, RW .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 460 (01) :1-12
[10]  
Driever W, 1996, DEVELOPMENT, V123, P37