BRCA1: exploring the links to transcription

被引：76

作者：

Monteiro, ANA ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Cell Biol, New York, NY 10021 USA

[2] Strang Canc Prevent Ctr, Oncol Mol Lab, New York, NY 10021 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(00)01632-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.

引用

页码：469 / 474

页数：6

共 44 条

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