Zinc fingers and a green thumb: manipulating gene expression in plants

被引：27

作者：

Segal, DJ

Stege, JT

Barbas, CF ^{[1
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

[4] Diversa Corp, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2003年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1369-5266(03)00007-4

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Artificial transcription factors can be rapidly constructed from predefined zinc-finger modules to regulate virtually any gene. Stable, heritable up- and downregulation of endogenous genes has been demonstrated in transgenic plants. These advances promise new approaches for creating functional knockouts and conditional overexpression, and for other gene discovery and manipulation applications in plants.

引用

页码：163 / 168

页数：6

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