Synthesis and antitumor activity of platinum(II) complexes of amino-cyclodextrin

被引：24

作者：

Matsumoto, K ^{[1
]}

Noguchi, Y

Yoshida, N

机构：

[1] Waseda Univ, Dept Chem, Tokyo 169, Japan

[2] Hokkaido Univ, Grad Sch Environm Earth Sci, Sapporo, Hokkaido 060, Japan

来源：

INORGANICA CHIMICA ACTA | 1998年 / 272卷 / 1-2期

关键词：

aminocyclodextrin complexes; platinum complexes; antitumor activity;

D O I：

10.1016/S0020-1693(97)06065-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Amino-(L) or ethylenediamine-(L') beta- or gamma-cyclodextrins, NH2-beta-CyD, beta-CyDen, NH2-beta-CyD, and gamma-CyDen, have been synthesized and their platinum complexes, [PtCl2(NH3)(NH2-CyD)], [PtCl2(beta-CyDen)], [PtCl2(NH3)(NH2-gamma-CyD)], and [PtCl2(gamma-CyDen)] have been prepared. The complexes were characterized by elemental analysis and NMR spectroscopy. The screening test for antitumor activity of these compounds against P388 in vivo showed only very marginal activity. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：162 / 167

页数：6

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