PDZ domains - glue and guide

被引:118
作者
van Ham, M [1 ]
Hendriks, W [1 ]
机构
[1] Univ Nijmegen, Nijmegen Ctr Mol Life Sci, Inst Cellular Signalling, Dept Cell Biol, NL-6525 GA Nijmegen, Netherlands
关键词
discs-large homologous region; GLGF repeat; MAGUK protein; protein domain; protein interactions; signal transduction;
D O I
10.1023/A:1023941703493
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
PDZ domains are small globular building blocks that are amongst the most abundant protein interaction domains in organisms. Over the past several years an avalanche of data has implicated these modules in the clustering, targeting and routing of associating proteins. An overview is given of the types of interactions displayed by PDZ domains and how this relates to the current knowledge on their spatial structure. Furthermore, the different levels on which PDZ - ligand binding can be regulated and the consequences of PDZ domain-mediated clustering for activity, routing and targeting of interacting proteins will be addressed. Finally, some cell and animal models that illustrate the impact of PDZ domain-containing proteins on (multi-) cellular processes will be discussed.
引用
收藏
页码:69 / 82
页数:14
相关论文
共 112 条
  • [1] In vivo requirement of the α-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4
    Adams, ME
    Mueller, HA
    Froehner, SC
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 155 (01) : 113 - 122
  • [2] Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon
    Anderson, CB
    Neufeld, KL
    White, RL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) : 8683 - 8688
  • [3] Receptor trafficking and the plasticity of excitatory synapses
    Barry, MF
    Ziff, EB
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (03) : 279 - 286
  • [4] PDZ domains: evolving classification
    Bezprozvanny, I
    Maximov, A
    [J]. FEBS LETTERS, 2002, 512 (1-3) : 347 - 349
  • [5] Classification of PDZ domains
    Bezprozvanny, I
    Maximov, A
    [J]. FEBS LETTERS, 2001, 509 (03) : 457 - 462
  • [6] Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1
    Bladt, F
    Tafuri, A
    Gelkop, S
    Langille, L
    Pawson, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) : 6816 - 6821
  • [7] A novel mechanism for regulating transforming growth factor β (TGF-β) signaling -: Functional modulation of type III TGF-β receptor expression through interaction with the PDZ domain protein, GIPC
    Blobe, GC
    Liu, XD
    Fang, SJJ
    How, T
    Lodish, HF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (43) : 39608 - 39617
  • [8] Periaxin mutations cause recessive Dejerine-Sottas neuropathy
    Boerkoel, CF
    Takashima, H
    Stankiewicz, P
    Garcia, CA
    Leber, SM
    Rhee-Morris, L
    Lupski, JR
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (02) : 325 - 333
  • [9] Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha 1-syntrophin mediated by PDZ domains
    Brenman, JE
    Chao, DS
    Gee, SH
    McGee, AW
    Craven, SE
    Santillano, DR
    Wu, ZQ
    Huang, F
    Xia, HH
    Peters, MF
    Froehner, SC
    Bredt, DS
    [J]. CELL, 1996, 84 (05) : 757 - 767
  • [10] Distinct structural requirements for clustering and immobilization of K+ channels by PSD-95
    Burke, NA
    Takimoto, K
    Li, DQ
    Han, WP
    Watkins, SC
    Levitan, ES
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 1999, 113 (01) : 71 - 80