Hayflick, his limit, and cellular ageing

被引：490

作者：

Shay, JW ^{[1
]}

Wright, WE ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2000年 / 1卷 / 01期

关键词：

D O I：

10.1038/35036093

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent - a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.

引用

页码：72 / 76

页数：5

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