Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans

被引：187

作者：

Klepser, ME

Wolfe, EJ

Jones, RN

Nightingale, CH

Pfaller, MA

机构：

[1] UNIV IOWA HOSP & CLIN,DEPT PATHOL,IOWA CITY,IA 52242

[2] HARTFORD HOSP,RES OFF,HARTFORD,CT 06102

[3] UNIV CONNECTICUT,SCH PHARM,STORRS,CT 06268

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 06期

关键词：

D O I：

10.1128/AAC.41.6.1392

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Time-kill curves mere determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIG. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

引用

页码：1392 / 1395

页数：4

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