Heat-shock proteins as death determinants

被引：142

作者：

Xanthoudakis, S ^{[1
]}

Nicholson, DW ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Dept Biochem & Mol Biol, Pointe Claire, PQ H9R 4P8, Canada

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1038/35023643

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The molecular pathways that mediate apoptosis are tightly regulated by a series of positive and negative signals, the balance of which determines whether or not cells commit suicide. New data from several laboratories now show that heat-shock proteins (HSPs) can influence this process through direct physical interaction with key components of the apoptotic machinery. These reports marry the survival (or death)-endowing properties of HSPs to the cell-death pathway.

引用

页码：E163 / E165

页数：3

共 19 条

[1] HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death [J].

Bardelli, A ;

Longati, P ;

Albero, D ;

Goruppi, S ;

Schneider, C ;

Ponzetto, C ;

Comoglio, PM .

EMBO JOURNAL, 1996, 15 (22) :6205-6212

[2] Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome [J].

Beere, HM ;

Wolf, BB ;

Cain, K ;

Mosser, DD ;

Mahboubi, A ;

Kuwana, T ;

Tailor, P ;

Morimoto, RI ;

Cohen, GM ;

Green, DR .

NATURE CELL BIOLOGY, 2000, 2 (08) :469-475

[3] Hsp27 negatively regulates cell death by interacting with cytochrome c [J].

Bruey, JM ;

Ducasse, C ;

Bonniaud, P ;

Ravagnan, L ;

Susin, SA ;

Diaz-Latoud, C ;

Gurbuxani, S ;

Arrigo, AP ;

Kroemer, G ;

Solary, E ;

Garrido, C .

NATURE CELL BIOLOGY, 2000, 2 (09) :645-652

[4] Apaf1 and the apoptotic machinery [J].

Cecconi, F .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (11) :1087-1098

[5] Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases [J].

Jäättelä, M ;

Wissing, D ;

Kokholm, K ;

Kallunki, T ;

Egeblad, M .

EMBO JOURNAL, 1998, 17 (21) :6124-6134

[6] Disruption of Hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-κB activation [J].

Lewis, J ;

Devin, A ;

Miller, A ;

Lin, Y ;

Rodriguez, Y ;

Neckers, L ;

Liu, ZG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10519-10526

[7] Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation [J].

Li, CY ;

Lee, JS ;

Ko, YG ;

Kim, JI ;

Seo, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25665-25671

[8] Caspase structure, proteolytic substrates, and function during apoptotic cell death [J].

Nicholson, DW .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (11) :1028-1042

[9] Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90 [J].

Pandey, P ;

Saleh, A ;

Nakazawa, A ;

Kumar, S ;

Srinivasula, SM ;

Kumar, V ;

Weichselbaum, R ;

Nalin, C ;

Alnemri, ES ;

Kufe, D ;

Kharbanda, S .

EMBO JOURNAL, 2000, 19 (16) :4310-4322

[10] Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3 [J].

Pandey, P ;

Farber, R ;

Nakazawa, A ;

Kumar, S ;

Bharti, A ;

Nalin, C ;

Weichselbaum, R ;

Kufe, D ;

Kharbanda, S .

ONCOGENE, 2000, 19 (16) :1975-1981

← 1 2 →