The histamine H3 receptor:: From gene cloning to H3 receptor drugs

被引：388

作者：

Leurs, R ^{[1
]}

Bakker, RA ^{[1
]}

Timmerman, H ^{[1
]}

de Esch, IJP ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Fac Sci, Amsterdam Ctr Drug Res, Div Med Chem, NL-1081 HV Amsterdam, Netherlands

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrd1631

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Since the cloning of the histamine H-3 receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well as for myocardial ischaemia, migraine and inflammatory diseases. Here, we discuss relevant information on this target protein and describe the development of various H-3 receptor agonists and antagonists, and their effects in preclinical animal models.

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页码：107 / U18

页数：16

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