Migraine treatment and placebo effect

被引：13

作者：

Speciali, Jose G. ^{[1
]}

Peres, Mario ^{[2
]}

Bigal, Marcelo E. ^{[3
,4
]}

机构：

[1] Univ Sao Paulo, Dept Neurol, Sch Med Ribeirao Preto, Sao Paulo, Brazil

[2] Albert Einstein Med Hosp, Div Neurol, Sao Paulo, Brazil

[3] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA

[4] Merck Res Labs, Whitehouse Stn, NJ USA

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2010年 / 10卷 / 03期

关键词：

acute treatment; migraine; placebo; placebo effect; preventive treatment; BLIND CLINICAL-TRIALS; TOXIN TYPE-A; PROPHYLACTIC TREATMENT; PARALLEL-GROUP; MULTICENTER; HEADACHE; ACUPUNCTURE; MECHANISMS; ANALGESIA; EFFICACY;

D O I：

10.1586/ERN.10.8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Placebos are typically defined as physiologically inactive substances that elicit a therapeutic response. The antipode of the placebo effect is the nocebo effect, or the negative effects of placebo, where unpleasant symptoms (e.g., adverse events) emerge after the administration of placebo. Placebo analgesia is one of the most striking examples of the cognitive modulation of pain perception. Herein we focus on the importance of placebo in headache research. We first review the mechanisms of the placebo effect. We then focus on the importance of placebo in the acute treatment of migraine. We follow by discussing the importance of placebo on the preventive treatment of migraine and our perspectives for the 5 years to come regarding the study of the placebos.

引用

页码：413 / 419

页数：7

共 43 条

[1]

Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems [J].

Amanzio, M ;

Benedetti, F .

JOURNAL OF NEUROSCIENCE, 1999, 19 (01) :484-494

[2]

A systematic review of adverse events in placebo groups of anti-migraine clinical trials [J].

Amanzio, Martina ;

Corazzini, Luca Latini ;

Vase, Lene ;

Benedetti, Fabrizio .

PAIN, 2009, 146 (03) :261-269

[3]

[Anonymous], 2006, HEADACHES

[4]

Is acupuncture analgesia an expectancy effect? Preliminary evidence based on participants' perceived assignments in two placebo-controlled trials [J].

Bausell, RB ;

Lao, LX ;

Bergman, S ;

Lee, WL ;

Berman, BM .

EVALUATION & THE HEALTH PROFESSIONS, 2005, 28 (01) :9-26

[5]

Neurobiological mechanisms of the placebo effect [J].

Benedetti, F ;

Mayberg, HS ;

Wager, TD ;

Stohler, CS ;

Zubieta, JK .

JOURNAL OF NEUROSCIENCE, 2005, 25 (45) :10390-10402

[6]

Migraine with aura versus migraine without aura: Pain intensity and associated symptom intensities after placebo [J].

Bigal, ME ;

Bordini, CA ;

Sheftell, FD ;

Speciali, JG ;

Bigal, JOM .

HEADACHE, 2002, 42 (09) :872-877

[7]

Bostick NA, 2008, J CLIN ETHIC, V19, P58

[8]

Not all placebos are the same: a debate on the ethics of placebo use in clinical trials versus clinical practice [J].

Cahana, Alex ;

Romagnioli, Simone .

JOURNAL OF ANESTHESIA, 2007, 21 (01) :102-105

[9]

Expectancy in Double-Blind Placebo-Controlled Trials: An Example from Alcohol Dependence [J].

Colagiuri, Ben ;

Morley, Kirsten ;

Boakes, Robert ;

Haber, Paul .

PSYCHOTHERAPY AND PSYCHOSOMATICS, 2009, 78 (03) :167-171

[10]

The importance of placebo in headache research [J].

Diener, H-C ;

Schorn, C. F. ;

Bingel, U. ;

Dodick, D. W. .

CEPHALALGIA, 2008, 28 (10) :1003-1011

← 1 2 3 4 5 →