Alterations of serotonin transmission in schizophrenia

被引：70

作者：

Abi-Dargham, Anissa ^{[1
]}

机构：

[1] Columbia Univ, New York State Psychiat Inst, Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA

来源：

INTEGRATING THE NEUROBIOLOGY OF SCHIZOPHRENIA | 2007年 / 78卷

关键词：

D O I：

10.1016/S0074-7742(06)78005-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A role for serotonin alterations in the pathophysiology of schizophrenia has long been suspected because of the psychotogenic effects of serotonergic agonists and the therapeutic effects of 5-HT2 antagonism. This chapter is a review of the evidence derived from pharmacological studies, postmortem, and imaging studies that have assessed the role of serotonin transmission in schizophrenia. While a clear picture of specific serotonergic alterations in schizophrenia has not emerged despite much research, this review reinforces a modulatory role of serotonergic agents on dopamine transmission in schizophrenia, which may contribute to the therapeutic effects of atypical antipsychotics.

引用

页码：133 / 164

页数：32

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