Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses

被引：79

作者：

Krause, Jens C. ^{[2
]}

Tumpey, Terrence M. ^{[3
]}

Huffman, Chelsey J. ^{[2
]}

McGraw, Patricia A. ^{[2
]}

Pearce, Melissa B. ^{[3
]}

Tsibane, Tshidi ^{[4
]}

Hai, Rong ^{[4
]}

Basler, Christopher F. ^{[4
]}

Crowe, James E., Jr. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Program Vaccine Sci, T2220 Med Ctr N,Dept Pediat, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA

[3] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA

[4] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 06期

关键词：

ANTIGENIC STRUCTURE; H-1; SUBTYPE; DETERMINANTS; MICE;

D O I：

10.1128/JVI.02184-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.

引用

页码：3127 / 3130

页数：4

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