Pathogenesis and manifestations of human herpesvirus-8 associated disorders

被引：23

作者：

Aoki, Y ^{[1
]}

Tosato, G ^{[1
]}

机构：

[1] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

SEMINARS IN HEMATOLOGY | 2003年 / 40卷 / 02期

关键词：

D O I：

10.1016/S0037-1963(03)70006-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human herpesvirus-8 (HHV-8), a recently discovered oncogenic human virus, is consistently associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). These disorders occur more frequently, but not exclusively, in human immunodeficiency virus (HIV)-infected individuals, and exhibit more aggressive clinical courses when developing in the setting of acquired immunodeficiency syndrome (AIDS). One of the most intriguing aspects of HHV-8-related disorders is the involvement of numerous growth factors in their pathogenesis. This review will focus on several HHV-8 gene products that exhibit proinflammatory and proangiogenic activities or act as transcriptional activators of cellular cytokines that are involved in the pathogenesis of HHV-8-related disorders.

引用

页码：143 / 153

页数：11

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