We evaluated the clinical value of a new index combining Delta ST/Delta heart rate (HR) index and ST/HR slope for diagnosing coronary artery disease (CAD) in patients on digoxin therapy. Exercise treadmill tests were performed by 72 patients on digoxin therapy. Simple HR-adjusted indexes of ST-segment depression during exercise (Delta ST/Delta HR index) and the decline calculated from the final 12 data points relating ST-segment depression to HR (ST/HR slope) were determined. A new index was obtained by subtracting the Delta ST/Delta HR index from the ST/HR slope. On thallium scintigraphy, 37 of the 72 patients showed reversible perfusion defects related to the diseased coronary artery. The new index derived from this ST-HR relation was 4.1 +/- 3.6 mu V/beats/min in the ischemic group and 1.3 +/- 1.0 mu V/beats/min in the group of patients without ischemia (p <0.0001). An ST-HR relation greater than or equal to 1.5 was found in 33 of the 37 patients in the ischemic group, and in 7 of the 35 patients without ischemia (p <0.0001). The sensitivity of this criterion for prediction of myocardial ischemia was 89%, the specificity was 80%, and the predictive accuracy was 85%. Thus, this new ST-HR index is useful for detecting CAD in patients on digoxin therapy. (C) 1998 by Excerpta Medica, Inc.
机构:
PRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USAPRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USA
GOLDSCHLAGER, N
;
SELZER, A
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PRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USAPRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USA
SELZER, A
;
COHN, K
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机构:
PRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USAPRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USA
机构:
PRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USAPRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USA
GOLDSCHLAGER, N
;
SELZER, A
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h-index: 0
机构:
PRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USAPRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USA
SELZER, A
;
COHN, K
论文数: 0引用数: 0
h-index: 0
机构:
PRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USAPRESBYTERIAN HOSP, PACIFIC MED CTR, DIV CARDIOL, SAN FRANCISCO, CA 94115 USA