Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers

被引：32

作者：

Hirami, Y ^{[1
]}

Aoe, M ^{[1
]}

Tsukuda, K ^{[1
]}

Hara, F ^{[1
]}

Otani, Y ^{[1
]}

Koshimune, R ^{[1
]}

Hanabata, T ^{[1
]}

Nagahiro, I ^{[1
]}

Sano, Y ^{[1
]}

Date, H ^{[1
]}

Shimizu, N ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Canc & Thorac Surg, Okayama 7008558, Japan

来源：

CANCER LETTERS | 2004年 / 214卷 / 02期

关键词：

NSCLC; EGFR; P-Akt; HIF-1; alpha; immunohistochemistry;

D O I：

10.1016/j.canlet.2004.04.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxiainducible factor-1alpha(HIF-1alpha) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1alpha. expression. Significant correlation between P-Akt and HIF-1alpha (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P = 0.031). (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：157 / 164

页数：8

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