Interaction of [Pt(en)(phen)]2+ and [Pt(en)(phi)]2+ with the hexanucleotide d(GTCGAC)2:: Evidence for minor groove binding

被引：47

作者：

Collins, JG ^{[1
]}

Rixon, RM

Aldrich-Wright, JR

机构：

[1] Univ New S Wales, Univ Coll, Australian Def Force Acad, Sch Chem, Canberra, ACT 2600, Australia

[2] Univ Western Sydney, Dept Chem, Campbelltown, NSW, Australia

来源：

INORGANIC CHEMISTRY | 2000年 / 39卷 / 19期

关键词：

D O I：

10.1021/ic991488b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

1H NMR spectroscopy was used in studying the binding of [Pt(en)(phen)]2+ and [Pt(en)(phi)]2+ to the hexanucleotide d(GTCGAC)2. The results indicate that both square planar platinum(II) complexes bind the hexanucleotide by intercalation from the minor groove. This suggests that simple square planar metallointer-calators, like organic intercalators, have an intrinsic preference for the DNA minor groove.

引用

页码：4377 / 4379

页数：3

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