Sugar sensing based on induced pH changes

被引：30

作者：

Kim, Youngmi ^{[1
]}

Hilderbrand, Scott A. ^{[1
]}

Weissleder, Ralph ^{[1
]}

Tung, Ching-Hsuan ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 22期

关键词：

D O I：

10.1039/b700741h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A sensory assembly consisting of a pH sensitive NIR dye and an arylboronic acid shows ratiometric absorption changes with increased fluorescence intensity upon addition of sugar in aqueous media; this demonstrates a new signal transduction mechanism for the detection of sugar based on pH changes induced in the microenvironment of the sensory assembly.

引用

页码：2299 / 2301

页数：3

共 23 条

[1] A glucose-sensing contact lens: from bench top to patient [J].

Badugu, R ;

Lakowicz, JR ;

Geddes, CD .

CURRENT OPINION IN BIOTECHNOLOGY, 2005, 16 (01) :100-107

[2] Monoboronic acid sensor that displays anomalous fluorescence sensitivity to glucose [J].

Cao, HS ;

Diaz, DI ;

DiCesare, N ;

Lakowicz, JR ;

Heagy, MD .

ORGANIC LETTERS, 2002, 4 (09) :1503-1505

[3]

CAO X, 2005, TETRAHEDRON, V61, P9111

[4] Wavelength-ratiometric probes for saccharides based on donor-acceptor diphenylpolyenes [J].

Di Cesare, N ;

Lakowicz, JR .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2001, 143 (01) :39-47

[5] An improved class of sugar-binding boronic acids, soluble and capable of complexing glycosides in neutral water [J].

Dowlut, M ;

Hall, DG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (13) :4226-4227

[6]

Han MS, 2002, ANGEW CHEM INT EDIT, V41, P3809, DOI 10.1002/1521-3773(20021018)41:20<3809::AID-ANIE3809>3.0.CO

[7]

2-N

[8] Synthetic receptors [J].

Hartley, JH ;

James, TD ;

Ward, CJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (19) :3155-3184

[9]

HILDERBRAND SA, IN PRESS

[10]

James TD, 2002, TOP CURR CHEM, V218, P159

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