Age-related changes in diurnal acetylcholine release in the prefrontal cortex of male rats as measured by microdialysis

被引：56

作者：

Mitsushima, D ^{[1
]}

Mizuno, T ^{[1
]}

Kimura, F ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV, SCH MED, DEPT PHYSIOL, KANAZAWA KU, YOKOHAMA, KANAGAWA 236, JAPAN

来源：

NEUROSCIENCE | 1996年 / 72卷 / 02期

关键词：

acetylcholine; aging; diurnal rhythm; daily rhythm; spontaneous motor activity; prefrontal cortex;

D O I：

10.1016/0306-4522(95)00572-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular levels of acetylcholine in the prefrontal cortex were measured using the microdialysis method in freely moving young (three to four months old) and old (23 to 24 months old) male rats over a period of 24 h to examine the effect of aging on prefrontal acetylcholine release. Prefrontal acetylcholine release during a 24 h period exhibited a diurnal variation with higher levels during the dark cycle than during the light cycle in young rats but not in old rats: In addition, prefrontal acetylcholine release was closely associated with spontaneous activity in young rats but not in old rats. The present study suggests that aging reduces diurnal changes in the prefrontal acetylcholine release and that there is a cross-correlation between the prefrontal acetylcholine release and spontaneous locomotor activity in male rats.

引用

页码：429 / 434

页数：6

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