Sonogashira cross-coupling reactions of aryl chlorides with alkynes catalysed by a tetraphosphine-palladium catalyst

被引：53

作者：

Feuerstein, M

Doucet, H

Santelli, M

机构：

[1] CNRS, UMR 6180, Synth Organ Lab, F-13397 Marseille 20, France

[2] Univ Aix Marseille 3, Fac Sci St Jerome, F-13397 Marseille 20, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期

关键词：

palladium; tetraphosphine; catalysis; cross-coupling; aryl chlorides; alkynes;

D O I：

10.1016/j.tetlet.2004.09.092

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of aryl chlorides undergoes cross-couplings with alkynes in good yields in the presence of [PdCl(C3H5)](2)/cis,cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as catalyst. A variety of aryl chlorides such as chloroacetophenone, chlorobenzonitrile, chloronitrobenzene, chloroanisole or chlorotoluene have been used successfully. The reaction also tolerates several alkynes such as phenylacetylene, dec-l-yne, ethynylcyclohexene or alk-l-ynols. Furthermore, this catalyst can be used at low loading with some substrates. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：8443 / 8446

页数：4

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