Synthesis and characterization of cyanine dye poly(ethylene glycol) conjugates as contrast agents for in vivo fluorescence imaging

被引：3

作者：

Licha, K ^{[1
]}

Riefke, B ^{[1
]}

Semmler, W ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Diagnost Forsch GMBH, D-14050 Berlin, Germany

来源：

OPTICAL AND IMAGING TECHNIQUES FOR BIOMONITORING III, PROCEEDINGS OF | 1998年 / 3196卷

关键词：

near-infrared dyes; poly(ethylene glycols); synthesis; fluorescence; photophysical properties;

D O I：

10.1117/12.297923

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cyanine dyes are promising near-infrared contrast agents because of their high molar absorption between 700 and 1000 nm, minimal phototoxicity and convenient synthetic availability. It is known that the derivatization of drugs or contrast agents with polyethylene glycol residues leads to enhanced retention in tumor tissue. The purpose of this study was to generate indotricarbocyanines with improved pharmacological properties enabling in vivo fluorescence detection of tumors. Several hydrophilic indotricarbocyanine-poly(ethylene glycol) conjugates of different molecular weight were synthesized and characterized physicochemically (partition coefficients, mass distribution) and photophysically (absorption and fluorescence properties in physiological media) in older to test their applicability as near infrared contrast media.

引用

页码：98 / 102

页数：5