Chromatin challenges during DNA replication and repair

被引：580

作者：

Groth, Anja

Rocha, Walter

Verreault, Alain

Almouzni, Genevieve

机构：

[1] Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada

[2] Inst Curie, Lab Nucl Dynam & Genome Plast, UMR 218, CNRS, F-75248 Paris 5, France

来源：

CELL | 2007年 / 128卷 / 04期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.cell.2007.01.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin-maturation mechanisms that reproduce chromatin organization in the wake of DNA replication and repair. The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure. © 2007 Elsevier Inc. All rights reserved.

引用

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页码：721 / 733

页数：13

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