A lipid dependence in the formation of twin ion channels

被引：16

作者：

Al-Momani, L ^{[1
]}

Reiss, P ^{[1
]}

Koert, U ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 01期

关键词：

gramicidin A; ion channel; bilayer membrane; twin-channel; hydrophobic coupling;

D O I：

10.1016/j.bbrc.2004.12.170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gramicidin A derivative with a polyether linkage between both ethanolamine termini was synthesized and its ion channel properties were studied. The compound showed a duplication in the state of conductance for alkali cations in thick DOPC bilayer membranes, which is interpreted as the occurrence of twin-channels. In thinner DMPC membranes mono-channels were dominant. The influence of hydrophobic coupling on the mono channel/twin channel equilibrium is discussed. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：342 / 347

页数：6

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