Cryoconservation - archiving for the future

被引：53

作者：

Glenister, PH ^{[1
]}

Thornton, CE ^{[1
]}

机构：

[1] MRC, Mammalian Genet Unit, Harwell OX11 0RD, Berks, England

来源：

MAMMALIAN GENOME | 2000年 / 11卷 / 07期

关键词：

D O I：

10.1007/s003350010108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse genetics is set to play a pivotal role in the key post-genome challenge-the study of mammalian gene function. Addressing this challenge will involve the development and application of systematic mutagenesis approaches. The expanding mouse mutant resource that will result threatens to overwhelm the currently available animal facility space. Cryopreservation of both mouse embryos and spermatozoa is currently widely employed for the efficient archiving of mouse stocks. Distribution and dissemination of new and existing mouse strains is simplified by the availability of extensive frozen archives. Also, the availability of archives of frozen spermatozoa provides a potential powerful route for the production of backcross progeny for rapid genetic mapping. Moreover, frozen oocytes and ovaries may offer a valuable addition to the current cryopreservation approaches. Comprehensive mouse mutant archives will provide an essential resource for mammalian genetics throughout the 21(st) century.

引用

页码：565 / 571

页数：7

共 53 条

[1] Combining mutagenesis and genomics in the mouse - Closing the phenotype gap [J].

Brown, SDM ;

Peters, J .

TRENDS IN GENETICS, 1996, 12 (11) :433-435

[2] Mouse mutagenesis - systematic studies of mammalian gene function [J].

Brown, SDM ;

Nolan, PM .

HUMAN MOLECULAR GENETICS, 1998, 7 (10) :1627-1633

[3]

CANDY CJ, 1997, J REPROD FERTIL ABST, V19, P66

[4] NORMAL FERTILIZATION AND DEVELOPMENT OF FROZEN-THAWED MOUSE OOCYTES - PROTECTIVE ACTION OF CERTAIN MACROMOLECULES [J].

CARROLL, J ;

WOOD, MJ ;

WHITTINGHAM, DG .

BIOLOGY OF REPRODUCTION, 1993, 48 (03) :606-612

[5] TRANSPLANTATION OF FROZEN - THAWED MOUSE PRIMORDIAL FOLLICLES [J].

CARROLL, J ;

GOSDEN, RG .

HUMAN REPRODUCTION, 1993, 8 (08) :1163-1167

[6]

CARTHEW P, 1985, J REPROD FERTIL, V73, P207

[7]

CARTHEW P, 1983, J REPROD FERTIL, V69, P253, DOI 10.1530/jrf.0.0690253

[8] LARGE DELETIONS AND OTHER GROSS FORMS OF CHROMOSOME IMBALANCE COMPATIBLE WITH VIABILITY AND FERTILITY IN THE MOUSE [J].

CATTANACH, BM ;

BURTENSHAW, MD ;

RASBERRY, C ;

EVANS, EP .

NATURE GENETICS, 1993, 3 (01) :56-61

[9]

Cox SL, 1996, J REPROD FERTIL, V107, P315, DOI 10.1530/jrf.0.1070315

[10] EFFECT OF GENOTYPE ON THE EFFICIENCY OF MOUSE EMBRYO CRYOPRESERVATION BY VITRIFICATION OR SLOW FREEZING METHODS [J].

DINNYES, A ;

WALLACE, GA ;

RALL, WF .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1995, 40 (04) :429-435

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